Age-Related Histological Changes in Kidneys of Brown Norway Rat
نویسندگان
چکیده
In this study, age-dependent histological changes in the kidneys of Brown Norway rat, a strain useful for conducting aging research, were evaluated. Examination was performed at 3, 12, 18, 24 and 30 months of age. Sclerotic and hypertrophic changes of the glomeruli were observed, and quantitative scores of these changes persistently increased with age. A marginal increase in scores was observed for glomerular cystic changes and tubulointerstitial damage. Further, urothelial hyperplasia was observed in the renal papillae, particularly at 30 months of age. In conclusion, the findings of the present study demonstrate that the Brown Norway strain exhibits persistent, but mild progression of age-dependent renal histological changes.
منابع مشابه
Age-related changes in cardiac structure and function in Fischer 344 Brown Norway hybrid rats
Hacker, Timothy A., Susan H. McKiernan, Pamela S. Douglas, Jonathan Wanagat, and Judd M. Aiken. Age-related changes in cardiac structure and function in Fischer 344 Brown Norway hybrid rats. Am J Physiol Heart Circ Physiol 290: H304–H311, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00290.2005.— The effects of aging on cardiovascular function and cardiac structure were determin...
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